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David Brull

David Brull
Cardiologist, London


Dr Brull is a Consultant Interventional Cardiologist whose practice involves all aspects of clinical cardiology including: investigation and treatment of chest pain and breathlessness, hypertension, heart failure, palpitations and collapse, cardiovascular risk assessment, treatment of elevated cholesterol and perioperative cardiac assessment.


His main sub-specialty is coronary intervention (angioplasty and stenting) with an additional interest in the perioperative assessment of patients utilising cardiopulmonary exercise testing as a tool to screen patients prior to elective surgery.


Dr Brull qualified at the Royal Free Medical School in 1992. Since then has worked in several London teaching hospitals before his appointment as Consultant Cardiologist and Honorary Senior Lecturer to The Whittington Hospital and The Heart Hospital, University College Hospitals in October 2003.

    Clinical interests

  • Dr Brull’s main interest and specialist training is in percutaneous coronary intervention (angioplasty and stenting). This procedure is designed to alleviate angina (chest pain caused by poor blood flow to the heart), whereby a small balloon and expandable stent ("scaffolding") is inserted across blockages in the coronary arteries to restore blood flow. This procedure is also the most efficient method of treating heart attacks.

    In addition to his work in the field of coronary artery disease, Dr Brull runs a specialist perioperative risk assessment clinic for patients prior to elective general and bariatric surgery, working with a large multi-disciplinary team in order to reduce perioperative risk.

    Research interests

  • Dr Brull has published widely in a large number of peer-reviewed journals, particularly in the field of cardiovascular genetics and on the recovery from cardiac surgery.

    Key publications

    • Higher IL-6 levels but not IL6 -174G>C or -572G>C genotype are associated with post-operative complication following coronary artery bypass graft (CABG) surgery.Sanders J, Hawe E, Brull DJ, Hubbart C, Lowe GD, Rumley A, Humphries SE, Montgomery HE.Atherosclerosis. 2008 Sep 4. [Epub ahead of print]
    • Association of serum interleukin-6 concentration with a functional IL6 -6331T>C polymorphism. Smith AJ, D'Aiuto F, Palmen J, Cooper JA, Samuel J, Thompson S, Sanders J, Donos N, Nibali L, Brull D, Woo P, Humphries SE.Clin Chem. 2008 May;54(5):841-50. Epub 2008 Mar 20
    • Free Interleukin (IL)-18 levels, and the impact of IL18 and IL18BP genetic variation, in CHD patients and healthy men.  Thompson SR, Novick D, Stock CJ, Sanders J, Brull D, Cooper J, Woo P, Miller G, Rubinstein M, Humphries SE.Arterioscler Thromb Vasc Biol. 2007 Dec;27(12):2743-9. Epub 2007 Oct 19.
    • A cortical potential reflecting cardiac function. Gray MA, Taggart P, Sutton PM, Groves D, Holdright DR, Bradbury D, Brull D, Critchley HD.   Proc Natl Acad Sci U S A.2007 Apr 17;104(16):6818-23. Epub 2007 Apr 9.
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